Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632687 | 0.81 | AURKA (0.47) | ALDH1A1MEN1KMT2AAURKATP53 | |
| SCHEMBL6637485 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1HTTGAAKDM4E | |
| SCHEMBL5649534 | 0.77 | LIPE (0.47) | SMN1; SMN2ALDH1A1HTTKDM4EMEN1 | |
| SCHEMBL6633229 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1HTTGAAMEN1 | |
| SCHEMBL6629379 | 0.76 | NPC1 (0.46) | SMN1; SMN2KDM4EADORA3MEN1KMT2A | |
| SCHEMBL424289 | 0.76 | RAB9A (0.58) | SMN1; SMN2ALDH1A1GAAKDM4EADORA3 | |
| SCHEMBL427395 | 0.75 | RAB9A (0.58) | SMN1; SMN2ALDH1A1GAAKMT2AAURKA | |
| SCHEMBL6634859 | 0.74 | RAB9A (0.41) | SMN1; SMN2ALDH1A1HTTGAAKDM4E | |
| SCHEMBL6631787 | 0.73 | KMT2A (0.42) | SMN1; SMN2ALDH1A1HTTGAAMEN1 | |
| SCHEMBL5650551 | 0.72 | HPGD (0.47) | SMN1; SMN2ALDH1A1HTTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458375-A2 | COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |