Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HCN1 | O60741 | 1/20 | 0.56 |
| ▸ | HCN3 | Q9P1Z3 | 1/20 | 0.56 |
| ▸ | HCN2 | Q9UL51 | 1/20 | 0.56 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 15/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632413 | 0.84 | MC4R (0.59) | MAPTRAB9AMC4R | |
| SCHEMBL4374266 | 0.83 | OPRM1 (0.51) | MAPTHCN1HCN4RAB9AMC4R | |
| SCHEMBL27923663 | 0.78 | HCN1 (0.49) | MAPTHCN1HCN3HCN2HCN4 | |
| SCHEMBL27820393 | 0.76 | SIGMAR1 (0.46) | HCN1HCN3HCN2HCN4 | |
| SCHEMBL16511270 | 0.75 | SLC6A9 (0.64) | HCN1HCN3HCN2HCN4 | |
| Hydrochloric Acid SCHEMBL27839717 | 0.74 | SIGMAR1 (0.45) | HCN1HCN3HCN2HCN4 | |
| SCHEMBL27839716 | 0.73 | SIGMAR1 (0.46) | HCN1HCN3HCN2HCN4 | |
| Hydrochloric Acid SCHEMBL27820189 | 0.72 | SIGMAR1 (0.45) | HCN1HCN3HCN2HCN4 | |
| SCHEMBL2877082 | 0.72 | NPFFR1 (0.56) | LMNA | |
| SCHEMBL7249447 | 0.72 | ALDH1A1 (0.44) | MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465867-A1 | LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO | Neurocrine Biosciences, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003031410-A1 | LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-04-17 | — | — | WO | disclosed |