Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026364 | 0.91 | KDM4E (0.35) | HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4024972 | 0.80 | ADORA3 (0.39) | PTGS1MAPTHPGDKDM4EALDH1A1 | |
| SCHEMBL4025328 | 0.70 | TP53 (0.34) | PTGS1ERCC1FEN1ERCC4MAPT | |
| SCHEMBL4031399 | 0.70 | ERCC1 (0.49) | ERCC1FEN1ERCC4MAPTHPGD | |
| SCHEMBL4031394 | 0.70 | ERCC1 (0.49) | ERCC1FEN1ERCC4MAPTHPGD | |
| SCHEMBL4027375 | 0.68 | L3MBTL1 (0.49) | HPGDKDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL27276226 | 0.66 | OGFRL1 (0.49) | — | |
| SCHEMBL30710400 | 0.65 | TP53 (0.31) | PTGS1TP53 | |
| SCHEMBL27275782 | 0.65 | KDM5B (0.40) | MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL22927770 | 0.65 | NR3C1 (0.41) | PTGS1MAPTTP53ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062211-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-07-31 | — | — | WO | disclosed |