Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741225 | 0.85 | MTNR1A (0.57) | MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL7741232 | 0.78 | MTNR1A (0.57) | MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL7741222 | 0.78 | MTNR1A (0.57) | MTNR1AMTNR1BCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL5227187 | 0.75 | MTNR1A (0.59) | MTNR1AMTNR1BCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL7741227 | 0.73 | MTNR1A (0.47) | MTNR1AMTNR1BHSD17B10PTGS1AKR1C3 | |
| SCHEMBL11718070 | 0.71 | KDM4E (0.53) | MTNR1AMTNR1BHSD17B10ALDH1A1HPGD | |
| SCHEMBL3914252 | 0.71 | MTNR1A (0.64) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL30692247 | 0.71 | MTNR1A (0.64) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL2998855 | 0.70 | PAM (0.61) | CYP3A4ALDH1A1KDM4E | |
| SCHEMBL2998851 | 0.70 | PAM (0.61) | CYP3A4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047664-B1 | NOVEL TRICYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2004-05-19 | — | — | EP | disclosed |