Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633664 | 0.85 | MTNR1A (0.62) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28307709 | 0.75 | L3MBTL1 (0.55) | CYP1A2CYP2C19ALDH1A1HPGDLMNA | |
| SCHEMBL7741232 | 0.74 | MTNR1A (0.57) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7741222 | 0.74 | MTNR1A (0.57) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4752950 | 0.74 | MTNR1A (0.59) | MTNR1AMTNR1BALDH1A1HPGDMAPT | |
| SCHEMBL7741712 | 0.73 | MTNR1A (0.60) | MTNR1AMTNR1BTSHRALDH1A1HPGD | |
| SCHEMBL28204954 | 0.72 | CYP1A1 (0.50) | CYP1A2CYP3A4CYP2D6ALDH1A1HPGD | |
| SCHEMBL5227187 | 0.72 | MTNR1A (0.59) | MTNR1AMTNR1BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2691222 | 0.70 | CYP1A2 (0.65) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28566878 | 0.70 | CNR2 (0.57) | MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1247528-C | Novel tricyclic compounds, preparation method and pharmaceutical compositions containing same | SIRVIR LAB (FR) | 2006-03-29 | — | — | CN | disclosed |
| US-6423870-B1 | ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-07-23 | — | — | US | disclosed |
| CN-1285817-A | Novel tricyclic compounds, preparation method and pharmaceutical compositions containing same | ADIR (FR) | 2001-02-28 | — | — | CN | disclosed |