Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 4/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 3/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344823 | 0.77 | CES1 (0.46) | CES1FAAHNCEH1 | |
| SCHEMBL544960 | 0.76 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL11769571 | 0.74 | EPHX1 (0.70) | EPHX1ANPEPERAP1ERAP2SIGMAR1 | |
| SCHEMBL28351262 | 0.74 | CES1 (0.51) | CES1FAAHNCEH1SIGMAR1 | |
| Formamide SCHEMBL28728347 | 0.72 | CES1 (0.43) | CES1FAAHNCEH1 | |
| SCHEMBL4895850 | 0.72 | EPHX1 (0.56) | EPHX1ANPEPERAP1ERAP2SIGMAR1 | |
| SCHEMBL10535445 | 0.72 | TSHR (0.46) | — | |
| SCHEMBL527670 | 0.71 | CALM1 (0.44) | CES1FAAHNCEH1KMT2A | |
| SCHEMBL18531940 | 0.71 | EPHX1 (0.64) | EPHX1ANPEPERAP1ERAP2SIGMAR1 | |
| SCHEMBL5431177 | 0.71 | METAP2 (0.41) | CES1FAAHNCEH1ANPEPERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383748-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002051983-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-07-04 | — | — | WO | disclosed |