Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | PTPRG | P23470 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664894 | 0.76 | P2RX7 (0.36) | HPGDALDH1A1MAPTCYP1A2KMT2A | |
| SCHEMBL663585 | 0.68 | ALDH1A1 (0.37) | HPGDALDH1A1MAPTCYP1A2KMT2A | |
| SCHEMBL14685998 | 0.66 | HTT (0.45) | HPGDALDH1A1MAPTCYP1A2KMT2A | |
| SCHEMBL2516419 | 0.65 | ALDH1A1 (0.43) | HPGDALDH1A1MAPTCYP1A2KMT2A | |
| SCHEMBL663588 | 0.64 | ALDH1A1 (0.38) | HPGDALDH1A1MAPTCYP1A2KMT2A | |
| SCHEMBL154416 | 0.64 | PTGDR2 (0.44) | HPGDALDH1A1LMNAPTPRCPTPRG | |
| SCHEMBL664893 | 0.64 | MEN1 (0.41) | ALDH1A1KMT2ALMNAMEN1HTT | |
| SCHEMBL1759203 | 0.63 | NPC1 (0.47) | HPGDALDH1A1MAPTCYP1A2KMT2A | |
| SCHEMBL29426994 | 0.62 | GABRA1 (0.44) | HPGDALDH1A1CYP1A2LMNAHTT | |
| SCHEMBL43286 | 0.62 | GABRA1 (0.44) | HPGDALDH1A1CYP1A2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | HPGD 559/4885ALDH1A1 2104/4885MAPT 3436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.