Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2999658 | 0.78 | KDM4E (0.58) | MAPTCYP3A4MAPK1LMNAPMP22 | |
| SCHEMBL22015704 | 0.78 | CYP3A4 (0.62) | MAPTCYP3A4MAPK1LMNAALDH1A1 | |
| SCHEMBL3255665 | 0.78 | BCHE (0.53) | MAPTCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL29730423 | 0.78 | CYP1A2 (0.50) | MAPTCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL6637133 | 0.78 | CYP1A2 (0.50) | MAPTCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL1263795 | 0.78 | TGFBR1 (0.49) | MAPTCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL21033795 | 0.77 | CYP2A6 (0.57) | MAPTCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL17445467 | 0.76 | MAPT (0.49) | MAPTCYP3A4MAPK1LMNAAPEX1 | |
| SCHEMBL25302086 | 0.76 | ALDH1A1 (0.59) | MAPTCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL29350007 | 0.76 | ALDH1A1 (0.59) | MAPTCYP3A4MAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825184-B2 | FOR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1438048-A1 | 1,4-DISUBSTITUTED BENZO-FUSED UREA COMPOUNDS AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20030162968-A1 | 1,4-Disubstituted benzo-fused urea compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-08-28 | — | — | US | disclosed |
| WO-2003032989-A1 | 1,4-DISUBSTITUTED BENZO-FUSED UREA COMPOUNDS AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162968-A1 | 1,4-Disubstituted benzo-fused urea compounds | NFKBIA, MPO, RELA | MAPT 2231/4885CYP3A4 174/4885MAPK1 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.