SCHEMBL6637191

SCHEMBL6637191

COC(=O)c1ccc(N(C)C)cc1OS(=O)(=O)C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.44
TUBB4A P04350 2/20 0.41
TUBB P07437 2/20 0.41
TUBA3C P0DPH7 2/20 0.41
TUBA1B P68363 2/20 0.41
TUBA4A P68366 2/20 0.41
TUBB4B P68371 2/20 0.41
TUBB3 Q13509 2/20 0.41
TUBB2A Q13885 2/20 0.41
TUBB8 Q3ZCM7 2/20 0.41
TUBA3E Q6PEY2 2/20 0.41
TUBA1A Q71U36 2/20 0.41
TUBA1C Q9BQE3 2/20 0.41
TUBB6 Q9BUF5 2/20 0.41
TUBB2B Q9BVA1 2/20 0.41
TUBB1 Q9H4B7 2/20 0.41
CFTR P13569 1/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL294877 0.84 KDM4E (0.44) CFTRKMT2AMEN1LMNACYP1A2
SCHEMBL974920 0.83 HSD11B1 (0.45) L3MBTL1CFTRCYP1A2CYP2C19FFAR4
SCHEMBL26619763 0.82 CA12 (0.51) L3MBTL1CFTRLMNATSHRFFAR4
SCHEMBL6643810 0.82 HSP90AA1 (0.43) L3MBTL1CFTRLMNAFFAR4HSD17B10
SCHEMBL4634289 0.82 FFAR4 (0.52) L3MBTL1CFTRFFAR4HSD17B10EPAS1
SCHEMBL6645882 0.81 ABL1 (0.50) L3MBTL1CFTRKMT2AMEN1EPAS1
SCHEMBL16750947 0.81 CFTR (0.57) L3MBTL1CFTRKMT2AMEN1LMNA
SCHEMBL16593084 0.81 L3MBTL1 (0.42) L3MBTL1CFTRKMT2AFFAR4HSD17B10
SCHEMBL4951199 0.79 RAB9A (0.46) L3MBTL1KMT2AMEN1TSHRMAPT
SCHEMBL18822400 0.78 CA12 (0.46) HSD17B10MAPTALDH1A1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040157866-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-08-12 US disclosed
EP-1383760-A1 BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-28 EP disclosed
WO-2002090347-A1 AMIDE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040157866-A1 Amide compounds APOB, NR1H2, NR1H3 L3MBTL1 1486/4885TUBB4A 3949/4885TUBB 3027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.