Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 14/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281450 | 0.78 | MTNR1A (0.68) | MTNR1AMTNR1B | |
| SCHEMBL6640319 | 0.74 | SLC6A2 (0.43) | KDM4EALDH1A1HPGD | |
| SCHEMBL29477258 | 0.69 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL6638097 | 0.69 | MTNR1A (0.67) | MTNR1AMTNR1B | |
| SCHEMBL7273633 | 0.68 | MTNR1A (0.50) | MTNR1AMTNR1BHPGD | |
| Hydrochloric Acid SCHEMBL10617650 | 0.67 | HTR2A (0.46) | — | |
| SCHEMBL8881567 | 0.67 | MTNR1A (0.47) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL6632742 | 0.66 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL19658437 | 0.66 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL19322908 | 0.66 | MTNR1A (1.00) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047664-B1 | NOVEL TRICYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2004-05-19 | — | — | EP | disclosed |
| US-6423870-B1 | ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-07-23 | — | — | US | disclosed |