Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11136899 | 0.86 | LMNA (0.51) | LMNACHRM2CHRM4CHRM5THRB | |
| Hydrochloric Acid SCHEMBL11139509 | 0.86 | LMNA (0.51) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL7534318 | 0.86 | MEN1 (0.47) | LMNAMEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL11138346 | 0.85 | LMNA (0.50) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL10914396 | 0.84 | CYP2D6 (0.47) | LMNABLMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11136071 | 0.84 | SLC6A1 (0.57) | LMNABLMKMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL11139059 | 0.83 | LMNA (0.49) | LMNACHRM2CHRM4CHRM5THRB | |
| Hydrochloric Acid SCHEMBL11138951 | 0.82 | OPRK1 (0.61) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL11134238 | 0.79 | LMNA (0.46) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL9594492 | 0.78 | SIGMAR1 (0.41) | LMNABLMKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774132-B1 | Spirooxindole derivatives that act as analgesics | ASTRAZENECA AB (SE) | 2004-08-10 | — | — | US | disclosed |
| EP-1426375-A2 | Analgesic spiroindole derivatives | AstraZeneca AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-20040087800-A1 | Spirooxindole derivatives are analgesics for the treatment of chronic pain. | ASTRAZENECA AB | 2004-05-06 | — | — | US | disclosed |
| EP-1202994-B1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| CN-1361779-A | Novel compounds | ASTRAZENECA AB (SE) | 2002-07-31 | — | — | CN | disclosed |
| EP-1202994-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005790-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2001-01-25 | — | — | WO | disclosed |
| EP-0011447-B1 | BLOOD PLATELET AGGREGATION INHIBITORY 1-BENZYL-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES AND SALTS THEREOF; PHARMACEUTICAL COMPOSITIONS THEREOF; AND ANALOGY PROCESSES FOR THE MANUFACTURE THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-01-05 | — | — | EP | disclosed |
| US-4238488-A | ANTICOAGULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-09 | — | — | US | disclosed |
| EP-0011447-A1 | Blood platelet aggregation inhibitory 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid derivatives and salts thereof; pharmaceutical compositions thereof; and analogy processes for the manufacture thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-05-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087800-A1 | Spirooxindole derivatives are analgesics for the treatment of chronic pain. | OPRK1, OPRD1, OPRL1 | LMNA 3687/4885CHRM2 1021/4885CHRM4 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.