Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30052135 | 1.00 | MTNR1A (0.57) | MTNR1AMTNR1BLOXL2RHEBHRH3 | |
| SCHEMBL9375185 | 0.92 | MTNR1A (0.56) | MTNR1AMTNR1BLOXL2HRH3KDM4E | |
| SCHEMBL29417817 | 0.86 | MTNR1A (0.60) | MTNR1AMTNR1BLOXL2HRH3KDM4E | |
| SCHEMBL606161 | 0.86 | MTNR1A (0.60) | MTNR1AMTNR1BLOXL2HRH3KDM4E | |
| SCHEMBL29272703 | 0.85 | MTNR1A (0.59) | MTNR1AMTNR1BLOXL2HRH3KDM4E | |
| SCHEMBL12714834 | 0.83 | MTNR1A (0.66) | MTNR1AMTNR1BLOXL2HRH3KDM4E | |
| SCHEMBL27578457 | 0.83 | SIRT1 (0.64) | MTNR1AMTNR1BLOXL2KDM4EALDH1A1 | |
| SCHEMBL630523 | 0.83 | SIRT1 (0.64) | MTNR1AMTNR1BLOXL2KDM4EALDH1A1 | |
| Zinc Ion SCHEMBL30949479 | 0.82 | MTNR1A (0.56) | MTNR1AMTNR1BLOXL2HRH3KDM4E | |
| SCHEMBL2350320 | 0.82 | MTNR1A (0.56) | MTNR1AMTNR1BLOXL2HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1144529-A | Heterocyclic compounds, their preparation and use | NOVO NORDISK AS (DK) | 1997-03-05 | — | — | CN | claimed |
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | claimed |
| US-20120042882-A1 | PARTICLES WITH CHARGED SURFACE DOMAINS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
| US-20070105937-A1 | Indole-3-propionamide and derivatives thereof | PAPPOLLA MIGUEL | 2007-05-10 | — | — | US | disclosed |
| EP-1068199-B1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| EP-1068199-A2 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6150533-A | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051591-A2 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105937-A1 | Indole-3-propionamide and derivatives thereof | IDO1, INMT, IDO2 | MTNR1A 98/4885MTNR1B 168/4885LOXL2 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.