Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 3/20 | 0.36 |
| ▸ | PLAU | P00749 | 3/20 | 0.36 |
| ▸ | PLAT | P00750 | 3/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743186 | 0.83 | ADRA2A (0.50) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL3785285 | 0.83 | AOC3 (0.45) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL1996992 | 0.82 | F2 (0.50) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL327252 | 0.81 | LOXL2 (0.54) | PRSS1ST14PLGPLAUPLAT | |
| SCHEMBL20553484 | 0.81 | PRSS1 (0.54) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL25230264 | 0.79 | NPC1 (0.61) | NPC1CA1CA2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7443406 | 0.79 | LOXL2 (0.52) | PRSS1PLGPLAUPLATKLKB1 | |
| Hydrochloric Acid SCHEMBL6157588 | 0.79 | PRSS1 (0.52) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL3772999 | 0.79 | GRIN2D (0.58) | PRSS1F2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL13892098 | 0.79 | PRSS1 (0.38) | PRSS1F2PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106916104-B | For treating the drug of colitis | 牡丹江医学院 | 2019-08-27 | — | — | CN | disclosed |
| CN-106916104-A | medicine for treating colitis | 牡丹江医学院 | 2017-07-04 | — | — | CN | disclosed |
| EP-1073655-B1 | PHARMACEUTICALLY AVAILABLE PROTOBERBERINE SALTS DERIVATIVES, AND PROTOBERBERINE DERIVATIVES AND SALTS THEREOF | HANWHA CHEMICAL CORP (KR) | 2004-04-14 | — | — | EP | disclosed |
| EP-1073655-A1 | PHARMACEUTICALLY AVAILABLE PROTOBERBERINE SALTS DERIVATIVES, AND PROTOBERBERINE DERIVATIVES AND SALTS THEREOF | HANWHA CHEMICAL CORPORATION (KR) | 2001-02-07 | — | — | EP | disclosed |
| US-6030978-A | EXHIBIT FUNGICIDAL EFFECT OR GROWTH-INHIBITORY EFFECT AGAINST FUNGI INCLUDING CUTANEOUS FILAMENTOUS FUNGUS, SUCH AS EPIDERMOPHYTON, MICROSPORUM, TRICHOPHYTON, SPOROTHRIX SCHENCKII, ASPERGILLUS OR CANDIDA; NONTOXICITY; | HANWHA CORPORATION (KR) | 2000-02-29 | — | — | US | disclosed |
| US-6008356-A | BRBERINE SALT DERIVATIVE IS REACTED WITH SODIUM TETRABORATE AND POTASSIUM CARBONATE IN ALCOHOL SOLVEANT TO FORM INTERMEDIATE, REACTING INTERMEDIATE WITH ALKYL SUBSTITUENT IN ACETONITRILE SOLVENT, OXIDIZING THE FORMED INTERMEDIATE | HANWHA CORPORATION (KR) | 1999-12-28 | — | — | US | disclosed |
| WO-1999055704-A1 | PHARMACEUTICALLY AVAILABLE PROTOBERBERINE SALTS DERIVATIVES, AND PROTOBERBERINE DERIVATIVES AND SALTS THEREOF | HANWHA CHEMICAL CORPORATION (KR) | 1999-11-04 | — | — | WO | disclosed |
| US-4948808-A | ENZYME INHIBITORS | EISAI CO., LTD. (JP) | 1990-08-14 | — | — | US | disclosed |