SCHEMBL6645448

SCHEMBL6645448

Cc1ccc(C(=O)Nc2ccc(OCCc3ccccn3)cc2)c(N2CCCCC2)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.55
MAPT P10636 5/20 0.51
ALDH1A1 P00352 3/20 0.50
SCN10A Q9Y5Y9 2/20 0.50
MET P08581 2/20 0.49
RAB9A P51151 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
NPC1 O15118 3/20 0.44
PKM P14618 2/20 0.44
HTT P42858 1/20 0.44
KLF5 Q13887 1/20 0.44
MAPK14 Q16539 1/20 0.43
SMO Q99835 1/20 0.43
HTR1A P08908 1/20 0.42
HTR2A P28223 1/20 0.42
GAA P10253 1/20 0.41
MAPK1 P28482 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6644382 0.91 ALDH1A1 (0.46) L3MBTL1MAPTALDH1A1SCN10AMET
SCHEMBL6649434 0.88 L3MBTL1 (0.68) L3MBTL1MAPTALDH1A1SCN10AMET
SCHEMBL6647784 0.87 ALDH1A1 (0.52) L3MBTL1MAPTALDH1A1SCN10ARAB9A
SCHEMBL6649491 0.86 SCN10A (0.50) L3MBTL1MAPTALDH1A1SCN10ARAB9A
SCHEMBL6648292 0.82 SCN10A (0.47) L3MBTL1MAPTALDH1A1SCN10AMET
SCHEMBL6649755 0.82 PPARG (0.49) MAPTALDH1A1METRAB9ASMN1; SMN2
SCHEMBL6645860 0.82 SCN10A (0.48) L3MBTL1MAPTALDH1A1SCN10ARAB9A
SCHEMBL6644178 0.81 L3MBTL1 (0.56) L3MBTL1MAPTALDH1A1METRAB9A
SCHEMBL6646584 0.81 SCN10A (0.44) L3MBTL1MAPTALDH1A1SCN10AMET
SCHEMBL6645905 0.81 RAB9A (0.44) MAPTALDH1A1METRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040133008-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-07-08 US disclosed
WO-2004039795-A2 AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-05-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040133008-A1 Amide compounds APOB, APOL1, LDLR L3MBTL1 1609/4885MAPT 4101/4885ALDH1A1 2174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.