SCHEMBL6645562

SCHEMBL6645562

O=CC1CNCCN1Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.49
SIGMAR1 Q99720 2/20 0.49
SLC6A2 P23975 3/20 0.43
SLC6A4 P31645 3/20 0.43
SLC6A3 Q01959 2/20 0.43
MITF O75030 1/20 0.39
CXCR4 P61073 1/20 0.39
ALDH1A1 P00352 4/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
HIF1A Q16665 1/20 0.39
MAPT P10636 1/20 0.39
PARP1 P09874 1/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA4 P22748 2/20 0.38
CA9 Q16790 2/20 0.38
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9051387 0.86 CYP2C19 (0.48) CYP2C19SIGMAR1SLC6A2SLC6A4SLC6A3
SCHEMBL16882674 0.86 CYP2C19 (0.48) CYP2C19SIGMAR1SLC6A2SLC6A4SLC6A3
SCHEMBL6642409 0.85 MITF (0.48) SIGMAR1SLC6A2SLC6A4SLC6A3MITF
SCHEMBL9048276 0.85 ALDH1A1 (0.42) CYP2C19SIGMAR1CXCR4ALDH1A1MEN1
SCHEMBL27668148 0.85 ALDH1A1 (0.45) ALDH1A1MEN1KMT2AMAPT
SCHEMBL28364430 0.84 CYP2C19 (0.41) CYP2C19SIGMAR1ALDH1A1MEN1KMT2A
SCHEMBL27930152 0.83 CHRNB2 (0.46) ALDH1A1
SCHEMBL27610338 0.81 KDM4E (0.43) MITFALDH1A1HIF1A
SCHEMBL27831282 0.80 ALDH1A1 (0.48) SIGMAR1SLC6A4MITFALDH1A1MEN1
SCHEMBL27705364 0.79 SIGMAR1 (0.53) CYP2C19SIGMAR1SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110382494-A Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors 阿雷生物药品公司 2019-10-25 CN disclosed
EP-3242872-B1 (PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER GENENTECH INC (US) 2019-07-03 EP disclosed
WO-2017181117-A1 INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE BLUEPRINT MEDICINES CORPORATION (US) 2017-10-19 WO disclosed
CN-102282132-A Inhibitors of diacylglycerol acyltransferase 2011-12-14 CN disclosed
CN-101381365-B Dual action antibiotics MORPHOCHEM AG KOMB CHEMIE 2011-07-06 CN disclosed
CN-101952278-A 3-alkyl-piperazine derivatives and uses thereof HOFFMANN LA ROCHE 2011-01-19 CN disclosed
CN-101381365-A Dual action antibiotics MORPHOCHEM AG KOMB CHEMIE (DE) 2009-03-11 CN disclosed
CN-1630655-A Dual action antibiotics MORPHOCHEM AG FUER KOM (DE) 2005-06-22 CN disclosed
EP-1432705-A2 DUAL ACTION ANTIBIOTICS Morphochem Aktiengesellschaft Für Kombinatorische Chemie (DE) 2004-06-30 EP disclosed
WO-2003032962-A2 DUAL ACTION ANTIBIOTICS Morphochem Aktiengesellschaft für kombinatorische Chemie (DE) 2003-04-24 WO disclosed
WO-2003031441-A1 MULTIPLE ACTION COMPOUNDS MORPHOCHEN AKTIENGESELLSCHAFT FÜR KOMBINATORISCHE CHEMIE (DE) 2003-04-17 WO disclosed
WO-2003031443-A1 DUAL ACTIONS ANTIBIOTICS COMPRISING A OXAZOLDINONE AND A QUINOLONE OR NAPHTHYRIDINONE MOIETY Morphochem Aktiengesellschaft für kombinatorische Chemie (DE) 2003-04-17 WO disclosed