Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503657 | 0.87 | CYP2A6 (0.38) | TNKS2CYP2A6ALDH1A1KDM4EPTGS2 | |
| SCHEMBL30688503 | 0.72 | TNKS2 (0.36) | TNKS2 | |
| SCHEMBL29720392 | 0.72 | DRD2 (0.37) | TNKS2 | |
| SCHEMBL1176363 | 0.72 | DRD2 (0.37) | TNKS2 | |
| SCHEMBL15161193 | 0.72 | GAA (0.38) | TNKS2CYP2A6ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL28259357 | 0.70 | KDM4E (0.41) | ALDH1A1KDM4EPTGS2HSD17B10TSHR | |
| SCHEMBL1438677 | 0.68 | GAA (0.37) | TNKS2ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL2856444 | 0.68 | ALDH1A1 (0.38) | CYP2A6ALDH1A1KDM4EPTGS2RAB9A | |
| SCHEMBL28219230 | 0.68 | ALDH1A1 (0.33) | TNKS2ALDH1A1 | |
| SCHEMBL762345 | 0.68 | ALDH1A1 (0.34) | TNKS2ALDH1A1RAB9AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-B1 | 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH INC (US) | 2019-08-14 | — | — | EP | disclosed |
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |