Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279887 | 1.00 | POLB (0.39) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6650233 | 0.89 | LIPE (0.40) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7303078 | 0.80 | RAB9A (0.36) | TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11199882 | 0.79 | ALDH1A1 (0.42) | POLBTSHRALDH1A1SMN1; SMN2ALOX15 | |
| SCHEMBL20484557 | 0.74 | HTT (0.49) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL761922 | 0.72 | ALOX15 (0.45) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7303471 | 0.71 | HDAC1 (0.35) | — | |
| SCHEMBL7229706 | 0.71 | POLB (0.42) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2715883 | 0.71 | POLB (0.42) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7341471 | 0.71 | ALDH1A1 (0.42) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423167-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING QUINALDOYL-AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS | Elan Pharmaceuticals, Inc. (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003020370-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING QUINALDOYL-AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS | ELAN PHARMACEUTICALS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |