SCHEMBL6650653

SCHEMBL6650653

O=C(Cl)Oc1cc(CCl)on1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
POLB P06746 2/20 0.33
LMNA P02545 1/20 0.33
JAK2 O60674 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TMPRSS15 P98073 1/20 0.31
RAB9A P51151 3/20 0.31
SMPD1 P17405 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.31
NPC1 O15118 2/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
NOTUM Q6P988 1/20 0.30
EGFR P00533 1/20 0.30
GAA P10253 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6650328 0.86 ALDH1A1 (0.58) ALDH1A1HTTSMN1; SMN2POLBLMNA
SCHEMBL6651785 0.84 ALDH1A1 (0.57) ALDH1A1HTTSMN1; SMN2POLBLMNA
SCHEMBL9202062 0.81 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2POLBLMNAL3MBTL1
SCHEMBL6651488 0.79 ALDH1A1 (0.59) ALDH1A1HTTSMN1; SMN2LMNARAB9A
SCHEMBL8305554 0.74 TMPRSS15 (0.48) ALDH1A1HTTSMN1; SMN2LMNAL3MBTL1
SCHEMBL3765497 0.73
SCHEMBL3066466 0.73 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2RAB9ANPC1EGFR
SCHEMBL9566966 0.70 EGFR (0.46) ALDH1A1HTTSMN1; SMN2POLBLMNA
SCHEMBL5987816 0.69 ALDH1A1 (0.44) ALDH1A1HTTSMN1; SMN2POLBRAB9A
SCHEMBL7995559 0.69 ALDH1A1 (0.42) ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0956294-B1 THROMBIN INHIBITORS ABBOTT GMBH & CO KG (DE) 2004-06-09 EP disclosed
EP-1165601-A2 PRODRUGS OF THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-01-02 EP disclosed
EP-1051431-A1 THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2000-11-15 EP disclosed
WO-2000061609-A2 PRODRUGS OF THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2000-10-19 WO disclosed
EP-0956294-A1 THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1999-11-17 EP disclosed
WO-1999037668-A1 THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1999-07-29 WO disclosed
WO-1998006741-A1 THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1998-02-19 WO disclosed