Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565427 | 0.86 | HIF1A (0.33) | KDM4EMEN1ALDH1A1LMNACYP2C9 | |
| SCHEMBL6648587 | 0.86 | HIF1A (0.33) | KDM4EMEN1ALDH1A1LMNACYP2C9 | |
| SCHEMBL6649810 | 0.82 | ALDH1A1 (0.33) | KDM4EALDH1A1HSD17B10HIF1A | |
| SCHEMBL1984131 | 0.77 | EDNRA (0.33) | KDM4EMEN1ALDH1A1LMNACYP2C9 | |
| SCHEMBL1845200 | 0.77 | MEN1 (0.35) | KDM4EMEN1ALDH1A1LMNACYP2C9 | |
| SCHEMBL6650937 | 0.75 | GPR84 (0.37) | KDM4EALDH1A1LMNACYP2C9HPGD | |
| SCHEMBL6169861 | 0.75 | ATM (0.41) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL29566136 | 0.75 | GPR84 (0.37) | KDM4EALDH1A1LMNACYP2C9HPGD | |
| SCHEMBL12205494 | 0.74 | ACHE (0.38) | KDM4EMEN1ALDH1A1LMNACYP2C9 | |
| SCHEMBL8829122 | 0.74 | AHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835870-B1 | Photochromic substituted naphthopyrans | PPG IND OHIO INC (US) | 2004-03-03 | — | — | EP | claimed |
| EP-0835870-A1 | Photochromic substituted naphthopyrans | PPG INDUSTRIES, INC. (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835870-B1 | Photochromic substituted naphthopyrans | PPG IND OHIO INC (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-0835870-A1 | Photochromic substituted naphthopyrans | PPG INDUSTRIES, INC. (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5656206-A | OPHTHALIMIC LENSES; RADIATION TRANSPARENT; PHOTOCHROMISM | TRANSITIONS OPTICAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |