Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.59 |
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.53 |
| ▸ | HTR3B | O95264 | 2/20 | 0.53 |
| ▸ | HTR3A | P46098 | 2/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | HTR5A | P47898 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | KHK | P50053 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909484 | 0.88 | HTR7 (0.59) | HTR7HTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL18411537 | 0.85 | PDK2 (0.46) | HTR7HTR1APDK2 | |
| SCHEMBL6650889 | 0.81 | HTR7 (0.58) | HTR7HTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL3267995 | 0.81 | HTR7 (0.69) | HTR7HTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7491691 | 0.79 | HTR1A (0.36) | HTR7HTR1AHTR3AHTR5AHTR6 | |
| SCHEMBL1874346 | 0.79 | VCP (0.46) | KHKPDK2 | |
| SCHEMBL1200196 | 0.79 | HTR1A (0.48) | HTR7HTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL7591669 | 0.78 | HTR7 (0.67) | HTR7HTR1AHTR3EHTR3BHTR3A | |
| SCHEMBL478208 | 0.78 | ADRB1 (0.57) | HTR7HTR1AHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL8318106 | 0.76 | ADRB1 (0.55) | HTR7HTR1AHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1997370-B | Use of N-sulfamoyl-N' -arylpiperazines for the production of medicaments for the prophylaxis or treatment of obesity and related diseases | SOLVAY PHARM BV | 2011-06-01 | — | — | CN | disclosed |
| CN-1997370-A | Medicaments containing N-sulfamoyl-N' -arylpiperazines for the prophylaxis or treatment of obesity and related diseases | SOLVAY PHARM GMBH (DE) | 2007-07-11 | — | — | CN | disclosed |
| EP-1447099-A2 | Antineoplastic polyethylene conjugates of cytostatic compounds and pharmaceuticals comprising same | Kratz, Felix (DE) | 2004-08-18 | — | — | EP | disclosed |
| EP-0934081-B1 | ANTINEOPLASTIC CONJUGATES OF ALBUMIN | KRATZ FELIX (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-1389194-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002088101-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-11-07 | — | — | WO | disclosed |