Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676999 | 0.85 | GABRA1 (0.47) | GABRA1GABRB2POLBNR4A2ALDH1A1 | |
| SCHEMBL6652006 | 0.80 | ALDH1A1 (0.46) | GABRA1GABRB2POLBNR4A2ALDH1A1 | |
| SCHEMBL6647509 | 0.78 | NR4A2 (0.49) | GABRA1GABRB2KMT2ANR4A2 | |
| SCHEMBL6648434 | 0.77 | GABRA1 (0.46) | GABRA1GABRB2NR4A2 | |
| SCHEMBL6645714 | 0.74 | NR4A2 (0.39) | GABRA1GABRB2KMT2ANR4A2ALDH1A1 | |
| SCHEMBL4375343 | 0.74 | GABRG2 (0.53) | GABRA1KMT2ANR4A2 | |
| SCHEMBL6991795 | 0.72 | NR4A2 (0.51) | NR4A2ALDH1A1KDM4ETSHR | |
| SCHEMBL27804319 | 0.72 | HDAC1 (0.46) | POLBALDH1A1 | |
| SCHEMBL6699986 | 0.71 | NR4A2 (0.72) | GABRA1GABRB2NR4A2 | |
| SCHEMBL1007089 | 0.71 | NR4A2 (0.50) | KMT2ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474425-A1 | DEAZAPURINES AND USES THEREOF | Eisai Co. Ltd. (JP) | 2004-11-10 | — | — | EP | disclosed |
| WO-2004063336-A2 | USES OF DEAZAPURINES FOR THE TREATMENT OF REPERFUSION INJURIES, OSTEOPOROSIS AND/OR BONE METASTASIS | EISAI CO. LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |
| WO-2003057696-A1 | DEAZAPURINES AND USES THEREOF | EISAI CO. LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |