Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648434 | 0.91 | GABRA1 (0.46) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1760236 | 0.91 | NR4A2 (0.48) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL6649760 | 0.81 | SIGMAR1 (0.42) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1696922 | 0.81 | NR4A2 (0.51) | NR4A2MAPTCREBBPTUBB1 | |
| SCHEMBL6511301 | 0.80 | NR4A2 (0.50) | NR4A2MAPTCREBBPTUBB1 | |
| SCHEMBL5507447 | 0.80 | NR4A2 (0.72) | NR4A2MAPTCREBBPTUBB1 | |
| SCHEMBL30009696 | 0.80 | NR4A2 (0.50) | NR4A2MAPTCREBBPGABRA1TUBB1 | |
| SCHEMBL7360321 | 0.80 | NR4A2 (0.50) | NR4A2MAPTCREBBPGABRA1TUBB1 | |
| SCHEMBL31618837 | 0.80 | NR4A2 (0.56) | NR4A2MAPTCREBBPGABRA1GABRB2 | |
| SCHEMBL6647187 | 0.80 | ALDH1A1 (0.52) | NR4A2MAPTGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474425-A1 | DEAZAPURINES AND USES THEREOF | Eisai Co. Ltd. (JP) | 2004-11-10 | — | — | EP | disclosed |
| WO-2004063336-A2 | USES OF DEAZAPURINES FOR THE TREATMENT OF REPERFUSION INJURIES, OSTEOPOROSIS AND/OR BONE METASTASIS | EISAI CO. LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |
| WO-2003057696-A1 | DEAZAPURINES AND USES THEREOF | EISAI CO. LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |