Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 5/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823918 | 0.96 | LSS (0.48) | LSSHRH3NOS3NOS1NOS2 | |
| SCHEMBL23074668 | 0.79 | LSS (0.46) | LSSTDP1 | |
| SCHEMBL15114960 | 0.78 | GPR119 (0.46) | LSSHRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15114937 | 0.78 | LSS (0.53) | LSS | |
| SCHEMBL15114875 | 0.76 | LSS (0.41) | LSSHRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23640419 | 0.75 | HRH3 (0.42) | LSSHRH3NOS3NOS1NOS2 | |
| SCHEMBL12460718 | 0.75 | HRH3 (0.48) | LSSHRH3NOS3NOS1NOS2 | |
| SCHEMBL4325830 | 0.74 | ITGB3 (0.46) | TDP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6652163 | 0.73 | GNAI3 (0.44) | KDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4147694 | 0.73 | ITGB3 (0.45) | TDP1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143971-B1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PF MEDICAMENT (FR) | 2004-06-02 | — | — | EP | disclosed |