Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647801 | 0.78 | P2RX7 (0.52) | LMNAP2RX7CNR2ALDH1A1 | |
| SCHEMBL6651900 | 0.78 | P2RX7 (0.47) | KDM4ELMNASMN1; SMN2P2RX7CNR2 | |
| SCHEMBL6653472 | 0.76 | P2RX7 (0.45) | KDM4ELMNAP2RX7CNR2MAPT | |
| SCHEMBL6655639 | 0.75 | P2RX7 (0.45) | LMNASMN1; SMN2P2RX7CNR2ALDH1A1 | |
| SCHEMBL6686286 | 0.74 | P2RX7 (0.43) | KDM4EP2RX7 | |
| SCHEMBL6653481 | 0.74 | P2RX7 (0.45) | LMNAP2RX7ALDH1A1 | |
| SCHEMBL6651560 | 0.74 | P2RX7 (0.43) | LMNASMN1; SMN2P2RX7MCHR1 | |
| SCHEMBL6658009 | 0.73 | P2RX7 (0.42) | KDM4ESMN1; SMN2P2RX7MAPT | |
| SCHEMBL4498609 | 0.72 | P2RX7 (0.68) | P2RX7 | |
| Hydrochloric Acid SCHEMBL6661546 | 0.72 | ABCB11 (0.39) | LMNASMN1; SMN2P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | disclosed |