Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CRAT | P43155 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL8678519 | 0.91 | TSHR (0.53) | TSHRLMNAALDH1A1APEX1SLC22A16 | |
| Betaine SCHEMBL31467313 | 0.91 | — | — | |
| Glycinebetaine SCHEMBL2803780 | 0.91 | TSHR (0.53) | TSHRLMNAALDH1A1APEX1SLC22A16 | |
| Glycinebetaine SCHEMBL4900209 | 0.91 | — | — | |
| Glycinebetaine SCHEMBL7739 | 0.91 | — | — | |
| Glycinebetaine SCHEMBL9785894 | 0.89 | TSHR (0.46) | TSHRLMNAALDH1A1APEX1SLC22A16 | |
| Glycinebetaine SCHEMBL8725957 | 0.88 | — | — | |
| Glycinebetaine SCHEMBL8388807 | 0.88 | — | — | |
| Glycinebetaine SCHEMBL20703289 | 0.88 | — | — | |
| Glycinebetaine SCHEMBL4255367 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200054664-A1 | METABOLIC SUPPLEMENT FORMULATION AND METHODS OF USE FOR TREATING DEPRESSION AND ANXIETY | HAWKINS GERMAINE BERNARD (US) | 2020-02-20 | — | — | US | disclosed |
| EP-2516018-B1 | AQUEOUS ANTIPERSPIRANT/DEODORANT COMPOSITION | COLGATE PALMOLIVE CO (US) | 2018-04-25 | — | — | EP | disclosed |
| EP-2516016-B1 | ANHYDROUS LIQUID ANTIPERSPIRANT/DEODORANT COMPOSITION | COLGATE PALMOLIVE CO (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-2516017-B1 | METHOD OF MAKING AN ANHYDROUS LIQUID ANTIPERSPIRANT COMPOSITION | COLGATE PALMOLIVE CO (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9585825-B2 | Method of making an anhydrous liquid antiperspirant composition | COLGATE-PALMOLIVE COMPANY (US) | 2017-03-07 | — | — | US | disclosed |
| US-20140314701-A1 | ANHYDROUS LIQUID ANTIPERSPIRANT COMPOSITION | COLGATE PALMOLIVE CO (US) | 2014-10-23 | — | — | US | disclosed |
| US-8815222-B2 | Anhydrous liquid antiperspirant composition | Colgate—Palmolive Company (US) | 2014-08-26 | — | — | US | disclosed |
| EP-1853222-B1 | ENHANCED EFFICACY ALUMINUM OR ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALT COMPOSITIONS CONTAINING CALCIUM SALT(S) AND BETAINE | COLGATE PALMOLIVE CO (US) | 2014-05-28 | — | — | EP | disclosed |
| US-20140127151-A1 | METHOD OF MAKING AN ANHYDROUS LIQUID ANTIPERSPIRANT COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 2014-05-08 | — | — | US | disclosed |
| US-8663610-B2 | Method of making an anhydrous liquid antiperspirant composition | COLGATE-PALMOLIVE COMPANY (US) | 2014-03-04 | — | — | US | disclosed |
| WO-2008097716-A2 | ANTIPERSPIRANT/DEODORANT COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 2008-08-14 | — | — | WO | disclosed |
| US-20080187503-A1 | Antiperspirant/Deodorant Composition | COLGATE-PALMOLIVE COMPANY | 2008-08-07 | — | — | US | disclosed |
| WO-2008017839-A1 | POLYMERIC MICELLAR CLUSTERS AND THEIR USES IN FORMULATING DRUGS | THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) | 2008-02-14 | — | — | WO | disclosed |
| EP-1853222-A1 | ENHANCED EFFICACY ALUMINUM OR ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALT COMPOSITIONS CONTAINING CALCIUM SALT(S) AND BETAINE | Colgate-Palmolive Company (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20070196308-A1 | Antiperspirant clear gel with low glycol content | COLGATE-PALMOLIVE COMPANY | 2007-08-23 | — | — | US | disclosed |
| US-20060204463-A1 | Enhanced efficacy aluminum or aluminum-zirconium antiperspirant salt compositions containing calcium salt(s) and betaine | COLGATE-PALMOLIVE COMPANY | 2006-09-14 | — | — | US | disclosed |
| WO-2006091417-A1 | ENHANCED EFFICACY ALUMINUM OR ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALT COMPOSITIONS CONTAINING CALCIUM SALT(S) AND BETAINE | COLGATE-PALMOLIVE COMPANY (US) | 2006-08-31 | — | — | WO | disclosed |
| EP-1663136-A2 | ANTIPERSPIRANT CLEAR GEL WITH LOW GLYCOL CONTENT | Colgate-Palmolive Company (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025523-A2 | ANTIPERSPIRANT CLEAR GEL WITH LOW GLYCOL CONTENT | COLGATE-PALMOLIVE COMPANY (US) | 2005-03-24 | — | — | WO | disclosed |
| US-6049428-A | COATING A SUBSTRATE WITH A SOLUTION OF AN ORGANIC DYE OCCURRING IN THE LYOTROPIC LIQUID-CRYSTAL STATE IN A SOLVENT WHILE SIMULTANEOUSLY ORIENTING THE DYE AND REMOVING THE SOLVENT | OPTIVA, INC. (US) | 2000-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187503-A1 | Antiperspirant/Deodorant Composition | DRD4, DDT, OPRD1 | TSHR 2947/4885LMNA 4020/4885ALDH1A1 504/4885 |
| US-20070196308-A1 | Antiperspirant clear gel with low glycol content | DEGS1, CENPE, GCN1 | TSHR 4238/4885LMNA 3239/4885ALDH1A1 4553/4885 |
| US-20060204463-A1 | Enhanced efficacy aluminum or aluminum-zirconium antiperspirant salt compositions containing calcium salt(s) and betaine | SLC6A12, LBR, KCNN1 | TSHR 3916/4885LMNA 2849/4885ALDH1A1 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.