SCHEMBL6656429

SCHEMBL6656429

COC(=O)Oc1c(C)nc2ccccc2c1N

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.56
TP53 P04637 2/20 0.56
KMT2A Q03164 4/20 0.49
MEN1 O00255 2/20 0.49
ALDH1A1 P00352 4/20 0.49
HPGD P15428 3/20 0.49
CYP1A2 P05177 1/20 0.49
NUDT1 P36639 1/20 0.49
SMN1; SMN2 Q16637 3/20 0.47
KDM4E B2RXH2 3/20 0.45
TSHR P16473 2/20 0.45
PDE10A Q9Y233 1/20 0.44
ADORA3 P0DMS8 3/20 0.43
GLA P06280 2/20 0.43
CASP1 P29466 2/20 0.43
CASP7 P55210 2/20 0.43
CHRM2 P08172 1/20 0.43
ADRA2A P08913 1/20 0.43
CHRM1 P11229 1/20 0.43
NQO2 P16083 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7554133 0.87 HSD17B10 (0.60) HSD17B10TP53KMT2AMEN1ALDH1A1
SCHEMBL27552258 0.85 HSD17B10 (0.63) HSD17B10TP53KMT2AMEN1ALDH1A1
SCHEMBL6653706 0.82 KDM4E (0.46) HSD17B10TP53KMT2AMEN1ALDH1A1
SCHEMBL6654938 0.81 ALDH1A1 (0.47) KMT2AMEN1ALDH1A1CYP1A2SMN1; SMN2
SCHEMBL6650935 0.81 ACHE (0.42) HSD17B10TP53ACHEKCNH2
SCHEMBL29768761 0.80 POLB (0.58) HSD17B10TP53KMT2AALDH1A1HPGD
Hydrochloric Acid SCHEMBL9370250 0.79 POLB (0.56) HSD17B10TP53KMT2AALDH1A1HPGD
SCHEMBL6653650 0.77 KMT2A (0.54) KMT2AMEN1ALDH1A1HPGDSMN1; SMN2
SCHEMBL9688914 0.77 KDM4E (0.42) HSD17B10TP53KMT2AMEN1ALDH1A1
SCHEMBL7649523 0.77 HSD17B10 (0.72) HSD17B10TP53KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218401-B1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE AVENTIS PHARMA GMBH (DE) 2004-06-16 EP disclosed
EP-1218401-A1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE Aventis Pharma Deutschland GmbH (DE) 2002-07-03 EP disclosed
WO-2001021642-A1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-03-29 WO disclosed