SCHEMBL6654938

SCHEMBL6654938

COC(=O)Oc1c(C)nc2ccc(Br)cc2c1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
HTT P42858 1/20 0.47
CASP3 P42574 4/20 0.46
GAA P10253 2/20 0.45
KDM4E B2RXH2 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
RXFP1 Q9HBX9 3/20 0.44
PRNP P04156 2/20 0.44
PPARG P37231 1/20 0.44
NR2E3 Q9Y5X4 1/20 0.44
NCOR2 Q9Y618 1/20 0.44
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
MPO P05164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
MAPT P10636 2/20 0.40
TDP1 Q9NUW8 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7553304 0.88 ALDH1A1 (0.50) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL27515095 0.87 ALDH1A1 (0.52) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL6656429 0.81 HSD17B10 (0.56) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL7648675 0.79 ALDH1A1 (0.56) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL6653990 0.77 LMNA (0.45) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL6823101 0.76 ALDH1A1 (0.55) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL5198345 0.75 L3MBTL1 (0.54) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL6650935 0.71 ACHE (0.42) BCHEACHEGRIN1GRIN2A
SCHEMBL12575808 0.71 MPO (0.58) ALDH1A1HTTCASP3GAAKDM4E
SCHEMBL6651230 0.69 APP (0.47) ALDH1A1HTTKDM4EL3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218401-B1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE AVENTIS PHARMA GMBH (DE) 2004-06-16 EP disclosed
EP-1218401-A1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE Aventis Pharma Deutschland GmbH (DE) 2002-07-03 EP disclosed
WO-2001021642-A1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-03-29 WO disclosed