Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.68 |
| ▸ | MMP13 | P45452 | 12/20 | 0.67 |
| ▸ | MMP1 | P03956 | 8/20 | 0.67 |
| ▸ | MMP2 | P08253 | 5/20 | 0.61 |
| ▸ | MMP14 | P50281 | 4/20 | 0.61 |
| ▸ | MMP9 | P14780 | 4/20 | 0.61 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6660260 | 0.87 | ADAM17 (0.65) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL6786664 | 0.84 | ADAM17 (0.83) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL6626726 | 0.83 | ADAM17 (0.84) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL7325091 | 0.83 | ADAM17 (0.61) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL6786688 | 0.83 | ADAM17 (0.62) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL7325802 | 0.82 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL6654489 | 0.81 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL7365665 | 0.81 | ADAM17 (0.82) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL6264635 | 0.81 | ADAM17 (0.82) | ADAM17MMP13MMP1MMP2MMP14 | |
| SCHEMBL3939658 | 0.80 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20020147342-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors | AMERICAN CYANAMID COMPANY (US) | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147342-A1 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors | MMP12, MMP17, MMP14 | ADAM17 7/4885MMP13 12/4885MMP1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.