Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.57 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | FASN | P49327 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16835054 | 0.81 | DDB1 (0.51) | DDB1CRBNWNT3AJAK3JAK2 | |
| SCHEMBL3163972 | 0.80 | GPR119 (0.54) | JAK3JAK2PTK2NAMPTGPR119 | |
| SCHEMBL25964904 | 0.80 | MAOB (0.62) | KDM1AMAOB | |
| SCHEMBL29538073 | 0.80 | DDB1 (0.56) | DDB1CRBNWNT3AJAK2NAMPT | |
| SCHEMBL28401115 | 0.78 | DDB1 (0.69) | DDB1CRBNWNT3AJAK3JAK2 | |
| SCHEMBL377671 | 0.78 | ALDH1A1 (0.58) | DDB1CRBNGPR119CYP2D6HSD17B10 | |
| SCHEMBL30011373 | 0.78 | KDM1A (0.58) | KDM1AMAOB | |
| SCHEMBL12489357 | 0.77 | GPR119 (0.60) | DDB1CRBNWNT3AJAK3JAK2 | |
| SCHEMBL29980570 | 0.77 | GPR119 (0.60) | DDB1CRBNWNT3AJAK3JAK2 | |
| SCHEMBL22324899 | 0.77 | DDB1 (0.67) | DDB1CRBNWNT3AJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040560-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2015-05-26 | — | — | US | disclosed |
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2014-04-17 | — | — | US | disclosed |
| US-8637532-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-01-28 | — | — | US | disclosed |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | DDB1 310/4885CRBN 642/4885WNT3A 4292/4885 |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | DDB1 310/4885CRBN 642/4885WNT3A 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.