Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6339109 | 0.71 | SLC18A3 (0.43) | DRD2KDM4ECYP2D6USP2HRH4 | |
| SCHEMBL6339113 | 0.71 | SLC18A3 (0.43) | DRD2KDM4ECYP2D6USP2HRH4 | |
| SCHEMBL6339128 | 0.67 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL6340567 | 0.65 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL2925964 | 0.64 | HTR2C (0.54) | HRH4HTR6HTR1A | |
| SCHEMBL14713128 | 0.62 | SIGMAR1 (0.36) | DRD2KDM4ELMNAMAPTCYP2D6 | |
| SCHEMBL5599757 | 0.61 | SIGMAR1 (0.40) | DRD2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL6660960 | 0.61 | PRKCD (0.33) | KDM4EALDH1A1MAPT | |
| SCHEMBL1534147 | 0.60 | DAO (0.47) | KDM4EALDH1A1LMNAMAPTHRH4 | |
| SCHEMBL6170201 | 0.60 | NPC1 (0.62) | KDM4EMAPTHRH4TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470126-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064425-A1 | N-SUBSTITUTED SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER JAPAN INC. (JP) | 2003-08-07 | — | — | WO | disclosed |