Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CAD | P27708 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112148 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL28012631 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL18213891 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL112149 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL805601 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL8645598 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL14763884 | 0.97 | ALDH1A1 (0.53) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| Isopropyl Alcohol SCHEMBL27634778 | 0.95 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL31633373 | 0.94 | ALDH1A1 (0.50) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| Bicarbonate SCHEMBL28431654 | 0.92 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10ALOX15MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915449-B2 | Contacting the corresponding sulfur compound with complex, bas and oxidizer; oxidation; isolation | CEPHALON FRANCE (FR) | 2011-03-29 | — | — | US | claimed |
| US-7812193-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2010-10-12 | — | — | US | claimed |
| US-20080214868-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2008-09-04 | — | — | US | claimed |
| US-20080171896-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CEPHALON FRANCE (FR) | 2008-07-17 | — | — | US | claimed |
| US-7317126-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2008-01-08 | — | — | US | claimed |
| US-8889873-B2 | Process for the preparation of enantiomerically enriched proton pump inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2014-11-18 | — | — | US | disclosed |
| US-8759583-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | TEVA SANTE (FR) | 2014-06-24 | — | — | US | disclosed |
| US-20130066111-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CEPHALON FRANCE (FR) | 2013-03-14 | — | — | US | disclosed |
| US-8318979-B2 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2012-11-27 | — | — | US | disclosed |
| EP-1863760-B1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2012-10-03 | — | — | EP | disclosed |
| CN-101142176-B | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | CEPHALON FRANCE | 2012-06-06 | — | — | CN | disclosed |
| US-8183294-B2 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | Cephelon France (FR) | 2012-05-22 | — | — | US | disclosed |
| WO-2006097814-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2006-09-21 | — | — | WO | disclosed |
| EP-1702915-A1 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | CEPHALON FRANCE (FR) | 2006-09-20 | — | — | EP | disclosed |
| US-20060205706-A1 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | CEPHALON FRANCE (FR) | 2006-09-14 | — | — | US | disclosed |
| EP-1663963-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2006-06-07 | — | — | EP | disclosed |
| US-20050222257-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| US-20050080256-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | TEVA SANTE (FR) | 2005-04-14 | — | — | US | disclosed |
| WO-2005028428-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION | CEPHALON FRANCE (FR) | 2005-03-31 | — | — | WO | disclosed |
| EP-1516869-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CEPHALON FRANCE (FR) | 2005-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171896-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | MAOA, CYP2F1, MAOB | ALDH1A1 282/4885LMNA 3123/4885HSD17B10 1221/4885 |
| US-20080214868-A1 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION | CYP2F1, MAOA, MAOB | ALDH1A1 293/4885LMNA 3121/4885HSD17B10 1181/4885 |
| US-20130066111-A1 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation | CYP2F1, SULT1A1, SULT2A1 | ALDH1A1 186/4885LMNA 3126/4885HSD17B10 1327/4885 |
| US-20050222257-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | CYP2F1, SULT1A1, SULT2A1 | ALDH1A1 186/4885LMNA 3126/4885HSD17B10 1327/4885 |
| US-20060205706-A1 | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation | SULT1A1, TST, SULT2A1 | ALDH1A1 59/4885LMNA 4656/4885HSD17B10 283/4885 |
| US-20050080256-A1 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation | MAOA, CYP2F1, MAOB | ALDH1A1 282/4885LMNA 3123/4885HSD17B10 1221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.