Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | ADK | P55263 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747525 | 0.79 | MEN1 (0.46) | NPBWR1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10448853 | 0.78 | PTGS2 (0.74) | PTGS2MAPTRAB9APOLBPTGDR2 | |
| SCHEMBL4055359 | 0.78 | HSD17B10 (0.49) | NPBWR1MAPTRAB9ANPC1KMT2A | |
| SCHEMBL9292469 | 0.78 | NPC1 (0.44) | NPBWR1MAPTRAB9ANPC1KMT2A | |
| SCHEMBL28207049 | 0.78 | PTGS2 (0.73) | PTGS2MAPTRAB9APOLBPTGDR2 | |
| SCHEMBL1655585 | 0.77 | MAPT (0.56) | MAPTMTORADKNISCHRAB9A | |
| SCHEMBL8539529 | 0.77 | GPR35 (0.49) | NPBWR1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL5249670 | 0.77 | MAPT (0.56) | MAPTHPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL76309 | 0.77 | NPC1 (0.55) | MAPTMTORADKNISCHRAB9A | |
| SCHEMBL31463535 | 0.76 | AMY1A (0.48) | NPBWR1MAPTRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |