Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747525 | 0.84 | MEN1 (0.46) | NPBWR1MEN1NPC1HSP90AA1AGTR1 | |
| SCHEMBL9292469 | 0.82 | NPC1 (0.44) | NPBWR1GSK3BMEN1NPC1HSP90AA1 | |
| SCHEMBL8539529 | 0.82 | GPR35 (0.49) | NPBWR1MEN1NPC1HSP90AA1AGTR1 | |
| SCHEMBL5249670 | 0.82 | MAPT (0.56) | GSK3BMEN1NPC1HSP90AA1AGTR1 | |
| SCHEMBL8540776 | 0.81 | AMY1A (0.48) | NPBWR1GSK3BMEN1NPC1HSP90AA1 | |
| SCHEMBL31463535 | 0.81 | AMY1A (0.48) | NPBWR1GSK3BMEN1NPC1HSP90AA1 | |
| SCHEMBL8615132 | 0.79 | NPC1 (0.42) | NPBWR1GSK3BMEN1NPC1HSP90AA1 | |
| SCHEMBL10440889 | 0.79 | ABCC8 (0.43) | GSK3BMEN1NPC1HSP90AA1AGTR1 | |
| SCHEMBL8536767 | 0.79 | CYP3A4 (0.46) | NPBWR1MEN1NPC1HSP90AA1AGTR1 | |
| SCHEMBL8536769 | 0.79 | NPC1 (0.42) | NPBWR1GSK3BMEN1NPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009030952-A2 | PHENYLCARBOXAMIDE DERIVATIVES AS INHIBITORS AND EFFECTORS OF THE HEDGEHOG PATHWAY | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | WO | disclosed |