Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 3/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MTTP | P55157 | 4/20 | 0.40 |
| ▸ | APOB | P04114 | 3/20 | 0.40 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859183 | 0.89 | MAPT (0.49) | NPC1RAB9ASMN1; SMN2GMNNLMNA | |
| SCHEMBL5860306 | 0.80 | SMO (0.44) | NPC1RAB9ASMN1; SMN2PTGS1SMO | |
| SCHEMBL5860276 | 0.79 | PDE4B (0.43) | RAB9ASMN1; SMN2POLBGMNNLMNA | |
| SCHEMBL5860337 | 0.78 | APOB (0.44) | SMOMTTPAPOB | |
| SCHEMBL5859192 | 0.78 | PSMD14 (0.51) | RAB9AGAAPOLBLMNA | |
| SCHEMBL5862249 | 0.75 | MTTP (0.45) | GPR27AVPR2SMN1; SMN2GAAPOLB | |
| SCHEMBL5860012 | 0.75 | PPARA (0.46) | GPR27AVPR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5859923 | 0.75 | MAPT (0.49) | SMN1; SMN2LMNANPSR1 | |
| SCHEMBL5859855 | 0.73 | NPC1 (0.51) | NPC1RAB9AMAOBGAAPOLB | |
| SCHEMBL5860301 | 0.71 | SMO (0.44) | SMN1; SMN2SMOMTTPAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1437339-A1 | SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING NF-KAPPA B INHIBITING ACTIVITY | Daiichi Suntory Pharma Co., Ltd. (JP) | 2004-07-14 | — | — | EP | disclosed |