Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657486 | 0.91 | MTNR1A (0.57) | ROCK2ROCK1MTNR1AMTNR1BHPGD | |
| SCHEMBL6656183 | 0.91 | MTNR1A (0.57) | ROCK2ROCK1MTNR1AMTNR1BDRD2 | |
| SCHEMBL2735835 | 0.88 | KDM4E (0.57) | ROCK2ROCK1HPGDDRD3KDM4E | |
| SCHEMBL6661736 | 0.88 | KDM4E (0.64) | MTNR1AMTNR1BHPGDDRD2DRD3 | |
| SCHEMBL6658648 | 0.88 | DRD2 (0.57) | MTNR1AMTNR1BDRD2DRD3KDM4E | |
| SCHEMBL6661201 | 0.88 | FLT3 (0.58) | MTNR1AMTNR1BDRD2DRD3KDM4E | |
| SCHEMBL34468877 | 0.84 | HPGD (0.61) | HPGDKDM4EALDH1A1GAANPC1 | |
| SCHEMBL6885761 | 0.84 | KDM4E (0.51) | ROCK2ROCK1MTNR1AMTNR1BDRD2 | |
| SCHEMBL6660067 | 0.83 | MTNR1A (0.57) | MTNR1AMTNR1BDRD2DRD3KDM4E | |
| SCHEMBL6657213 | 0.83 | FLT3 (0.54) | MTNR1AMTNR1BDRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556034-B1 | INDOLE DERIVATIVES AS BETA-2 AGONISTS | PFIZER LTD (GB) | 2008-04-16 | — | — | EP | disclosed |
| CN-1723020-A | Indole derivatives as beta-2 agonists | PFIZER LTD (US) | 2006-01-18 | — | — | CN | disclosed |
| EP-1460064-A1 | Indole-2-carboxamide derivatives useful as beta-2 agonists | Pfizer Limited (GB) | 2004-09-22 | — | — | EP | disclosed |
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |