Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661461 | 0.88 | ROCK2 (0.59) | KDM4EMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL4919678 | 0.86 | FLT3 (0.61) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2735834 | 0.86 | FLT3 (0.61) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6657486 | 0.82 | MTNR1A (0.57) | KDM4EMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6656183 | 0.82 | MTNR1A (0.57) | KDM4EMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6661201 | 0.81 | FLT3 (0.58) | KDM4EMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL19476159 | 0.80 | NPC1 (0.70) | KDM4EMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6658648 | 0.79 | DRD2 (0.57) | KDM4EMTNR1AMTNR1BTAS1R3TAS1R1 | |
| SCHEMBL6657806 | 0.79 | DRD2 (0.54) | KDM4EMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL8759043 | 0.78 | HPGD (0.70) | MEN1KMT2ATAS1R3TAS1R1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |