Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661461 | 0.91 | ROCK2 (0.59) | MTNR1AMTNR1BFLT3DRD2DRD3 | |
| SCHEMBL6660067 | 0.89 | MTNR1A (0.57) | MTNR1AMTNR1BDRD2DRD3KDM4E | |
| SCHEMBL6656183 | 0.89 | MTNR1A (0.57) | MTNR1AMTNR1BFLT3DRD2DRD3 | |
| SCHEMBL6661201 | 0.86 | FLT3 (0.58) | MTNR1AMTNR1BFLT3DRD2DRD3 | |
| SCHEMBL6657213 | 0.82 | FLT3 (0.54) | MTNR1AMTNR1BFLT3DRD2DRD3 | |
| SCHEMBL6661736 | 0.82 | KDM4E (0.64) | MTNR1AMTNR1BFLT3DRD2DRD3 | |
| SCHEMBL6658648 | 0.81 | DRD2 (0.57) | MTNR1AMTNR1BDRD2DRD3KDM4E | |
| SCHEMBL6657726 | 0.80 | GAA (0.53) | MTNR1AMTNR1BDRD2DRD3KDM4E | |
| SCHEMBL2735835 | 0.80 | KDM4E (0.57) | FLT3DRD3KDM4EROCK2ROCK1 | |
| SCHEMBL22809795 | 0.79 | KDM4E (0.58) | MTNR1AMTNR1BDRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |