Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809795 | 0.81 | KDM4E (0.58) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL6659424 | 0.81 | KDM4E (0.60) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL6656620 | 0.81 | POLB (0.59) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL6656151 | 0.80 | HDAC2 (0.62) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL6661461 | 0.80 | ROCK2 (0.59) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL19476088 | 0.79 | NPC1 (0.61) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL6658648 | 0.78 | DRD2 (0.57) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL2735969 | 0.77 | CA12 (0.72) | DRD2DRD3KDM4EALDH1A1GAA | |
| SCHEMBL9397179 | 0.77 | DRD2 (0.74) | DRD2DRD3HTR2CKDM4EALDH1A1 | |
| SCHEMBL6656183 | 0.76 | MTNR1A (0.57) | DRD2DRD3HTR2CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |