Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6663471 | 1.00 | HDAC1 (0.52) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL19748691 | 0.89 | CTSB (0.54) | HDAC1HDAC6MEN1KMT2AATM | |
| SCHEMBL32677013 | 0.89 | CTSB (0.54) | HDAC1HDAC6MEN1KMT2AATM | |
| SCHEMBL14209576 | 0.88 | HDAC1 (0.49) | HDAC1HDAC6MEN1KMT2AATM | |
| SCHEMBL4402346 | 0.86 | HDAC3 (0.53) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL12813341 | 0.86 | FPR2 (0.53) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL12813343 | 0.86 | FPR2 (0.53) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL31753512 | 0.86 | FPR2 (0.53) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL32677233 | 0.85 | CTSB (0.51) | HDAC1HDAC6MEN1KMT2AATM | |
| SCHEMBL32677070 | 0.85 | CTSB (0.51) | HDAC1HDAC6MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030854-B1 | CATALYSTS FOR ASYMMETRIC SYNTHESIS CONTAINING RIGID CHIRAL LIGANDS | PENN STATE RES FOUND (US) | 2004-08-18 | — | — | EP | disclosed |
| US-6380416-B2 | CHIRAL BIDENTATE PHOSPHINE LIGANDS WITH CYCLIC RINGS TO RESTRICT CONFORMATIONAL FLEXIBILITY OF THE LIGANDS TO ENHANCE EFFICIENCY; STEREOSELECTIVE HYDROGENATION OF KETONES TO ALCOHOLS, AND A-ACETOAMIDOCINNAMIC ACID TO ACYLAMINO ACIDS | THE PENN STATE RESEARCH FOUNDATION | 2002-04-30 | — | — | US | disclosed |
| US-20010047113-A1 | Chiral bidentate phosphine ligands with cyclic rings to restrict conformational flexibility of the ligands to enhance efficiency; stereoselective hydrogenation of ketones to alcohols, and a-acetoamidocinnamic acid to acylamino acids | THE PENN STATE RESEARCH FOUNDATION | 2001-11-29 | — | — | US | disclosed |
| US-6278024-B1 | AS CATALYSTS FOR ASSYMETRIC SYNTHESIS | THE PENN STATE RESEARCH FOUNDATION | 2001-08-21 | — | — | US | disclosed |
| US-6207868-B1 | BASED ON CHIRAL BIDENTATE PHOSPHINE LIGANDS WITH CYCLIC RING STRUCTURES TO RESTRICT CONFORMATIONAL FLEXIBILITY, ASYMMETRIC SYNTHESIS OF ALCOHOLS BY ENANTIOSELECTIVE HYDROGENATION OF KETONES CATALYZED BY THE CHIRAL LIGANDS | THE PENN STATE RESEARCH FOUNDATION | 2001-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047113-A1 | Chiral bidentate phosphine ligands with cyclic rings to restrict conformational flexibility of the ligands to enhance efficiency; stereoselective hydrogenation of ketones to alcohols, and a-acetoamidocinnamic acid to acylamino acids | ADH1A, AASDHPPT, AADAT | HDAC1 578/4885HDAC6 724/4885HDAC3 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.