Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | POLA1 | P09884 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667774 | 0.83 | CHEK1 (0.46) | AKR1C3NR1H4CHEK1POLA1KCNH2 | |
| SCHEMBL6667762 | 0.83 | MEN1 (0.42) | POLA1KCNH2RAB9A | |
| SCHEMBL7478855 | 0.82 | POLA1 (0.39) | AKR1C3NR1H4CHEK1POLA1KCNH2 | |
| SCHEMBL6667470 | 0.82 | INSR (0.39) | AKR1C3NR1H4POLA1KCNH2NPC1 | |
| SCHEMBL7472513 | 0.82 | AKR1C3 (0.36) | AKR1C3NR1H4CHEK1POLA1KCNH2 | |
| SCHEMBL7007040 | 0.81 | PDE1B (0.45) | AKR1C3NR1H4CHEK1POLA1KCNH2 | |
| SCHEMBL6669285 | 0.81 | POLA1 (0.35) | AKR1C3NR1H4POLA1KCNH2NPC1 | |
| SCHEMBL7475511 | 0.80 | NR1H4 (0.38) | AKR1C3NR1H4CHEK1POLA1KCNH2 | |
| SCHEMBL6670571 | 0.77 | KDM4E (0.39) | KCNH2PDE1BENPP2 | |
| SCHEMBL6974853 | 0.75 | KCNH2 (0.47) | POLA1KCNH2NPC1RAB9AENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |