Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23863044 | 0.95 | HCRTR1 (0.60) | HCRTR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3118866 | 0.90 | KIF11 (0.52) | HCRTR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5067366 | 0.83 | ALDH1A1 (0.64) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25263341 | 0.82 | GAA (0.54) | HCRTR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31486166 | 0.80 | HCRTR1 (0.57) | HCRTR1KDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6670599 | 0.79 | HCRTR1 (0.50) | HCRTR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7215720 | 0.78 | ALOX5 (0.56) | HCRTR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL23863111 | 0.78 | KIF11 (0.60) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2390518 | 0.77 | ALDH1A1 (0.67) | KDM4EALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL68639 | 0.77 | KDM4E (0.85) | HCRTR1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442039-A1 | PYRIMIDO (4,5-B) INDOLE DERIVATIVES | Bayer HealthCare AG (DE) | 2004-08-04 | — | — | EP | disclosed |
| WO-2004058764-A1 | 4-PHENYL-PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-07-15 | — | — | WO | disclosed |
| WO-2003037898-A1 | PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-05-08 | — | — | WO | disclosed |