⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29631981 | 0.83 | KDM4E (0.42) | — | |
| SCHEMBL31549503 | 0.72 | TGFBR1 (0.37) | — | |
| SCHEMBL29024583 | 0.70 | MME (0.38) | — | |
| SCHEMBL8594034 | 0.66 | MME (0.42) | — | |
| SCHEMBL29024434 | 0.66 | MME (0.49) | — | |
| SCHEMBL29024437 | 0.66 | KMT2A (0.43) | — | |
| SCHEMBL1824031 | 0.65 | FOLH1 (0.45) | — | |
| SCHEMBL1262924 | 0.65 | — | — | |
| SCHEMBL8829463 | 0.63 | KDM4E (0.46) | — | |
| SCHEMBL31443270 | 0.63 | MMP1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040204357-A1 | Modulator of the megalin-mediated uptake of radiotherapeutics and/or radiodiagnostics into kidney cells and their use in therapy and diagnostics | SCHERING AG (DE) | 2004-10-14 | — | — | US | disclosed |
| WO-2004084953-A1 | MODULATORS OF THE MEGALIN-MEDIATED UPTAKE OF RADIOTHERAPEUTICS AND/OR RADIODIAGNOSTICS INTO KIDNEY CELLS AND THEIR USE IN THERAPY AND DIAGNOSTICS | SCHERING AG (DE) | 2004-10-07 | — | — | WO | disclosed |
| EP-1462119-A1 | Modulators of the megalin-mediated uptake of radiotherapeutics and/or radiodiagnostics into kidney cells and their use in therapy and diagnostics | Schering AG (DE) | 2004-09-29 | — | — | EP | disclosed |