SCHEMBL6671845

SCHEMBL6671845

Cc1ccc(-c2ccccc2)c(C(=O)Nc2ccc3c(c2)CCN3C(=O)Cc2ccnc(N)n2)c1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
EIF2AK3 Q9NZJ5 8/20 0.42
EIF2AK1 Q9BQI3 2/20 0.42
MAPT P10636 3/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
RIPK1 Q13546 2/20 0.41
LCK P06239 1/20 0.39
AURKB Q96GD4 1/20 0.39
SYK P43405 2/20 0.39
CREBBP Q92793 1/20 0.39
POLB P06746 2/20 0.39
RXFP1 Q9HBX9 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
OPRL1 P41146 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6804764 0.92 MAPT (0.44) CYP11B1CYP11B2EIF2AK3EIF2AK1MAPT
SCHEMBL6669273 0.91 CYP11B1 (0.44) CYP11B1CYP11B2EIF2AK3EIF2AK1RIPK1
SCHEMBL6665119 0.89 EIF2AK3 (0.44) CYP11B1CYP11B2EIF2AK3MAPTNPC1
SCHEMBL6667572 0.89 HTR2A (0.43) CYP11B1CYP11B2EIF2AK3EIF2AK1MAPT
Hydrochloric Acid SCHEMBL6667512 0.88 EIF2AK3 (0.43) CYP11B1CYP11B2EIF2AK3MAPTNPC1
SCHEMBL6664878 0.88 EIF2AK3 (0.48) CYP11B1CYP11B2EIF2AK3MAPTNPC1
SCHEMBL6670249 0.86 MAPT (0.42) EIF2AK3EIF2AK1MAPTNPC1TP53
SCHEMBL6805312 0.85 EIF2AK3 (0.43) CYP11B1CYP11B2EIF2AK3EIF2AK1RIPK1
SCHEMBL6667964 0.85 EIF2AK3 (0.50) CYP11B1CYP11B2EIF2AK3MAPTNPC1
SCHEMBL6667068 0.84 MAPT (0.43) CYP11B1CYP11B2EIF2AK3EIF2AK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1383760-A1 BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-28 EP claimed
WO-2002090347-A1 AMIDE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-14 WO claimed
EP-1383760-A1 BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-28 EP disclosed
WO-2002090347-A1 AMIDE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-14 WO disclosed