Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672447 | 0.79 | AKR1B1 (0.46) | AKR1B1 | |
| SCHEMBL6672828 | 0.70 | AKR1B1 (0.47) | AKR1B1 | |
| SCHEMBL6207869 | 0.67 | AKR1B1 (1.00) | AKR1B1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL19737857 | 0.66 | KDM4E (0.55) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL4452028 | 0.65 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6238316 | 0.64 | AKR1B1 (0.53) | AKR1B1POLBLMNAHSD17B10 | |
| SCHEMBL4451325 | 0.64 | AKR1B1 (0.68) | AKR1B1ALDH1A1POLBHPGD | |
| SCHEMBL8480289 | 0.63 | LMNA (0.60) | AKR1B1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL8478264 | 0.60 | LMNA (0.60) | AKR1B1SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL8126786 | 0.60 | ABCB1 (0.53) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-B1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | claimed |