Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864739 | 0.77 | MAPK14 (0.78) | MAPK14 | |
| SCHEMBL9525943 | 0.70 | MEN1 (0.65) | MAPK14ACHEMAPTHPGDMEN1 | |
| SCHEMBL6672641 | 0.66 | MAPK14 (0.79) | MAPK14ALOX5 | |
| SCHEMBL21905625 | 0.66 | STING1 (0.46) | ACHEMAPTMEN1KMT2A | |
| SCHEMBL8543123 | 0.62 | KMT2A (0.56) | MAPK14MAPTHPGDMEN1GAA | |
| SCHEMBL6935266 | 0.62 | ACHE (0.66) | ACHEESR2ESR1 | |
| SCHEMBL29979385 | 0.62 | ACHE (0.66) | ACHEESR2ESR1 | |
| SCHEMBL13799411 | 0.61 | DRD2 (0.50) | MAPTHPGDMEN1GAAKMT2A | |
| SCHEMBL5216315 | 0.61 | SLC6A2 (0.58) | ACHEALOX5HPGDGAA | |
| SCHEMBL30596244 | 0.61 | MAPK14 (0.55) | MAPK14AADATALOX5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345603-A4 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1345603-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | Merck & Co., Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002058695-A9 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2003-09-12 | — | — | WO | disclosed |
| WO-2002058695-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2002-08-01 | — | — | WO | disclosed |