Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | LPO | P22079 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682004 | 0.82 | CHRNB2 (0.40) | CHRNB2CHRNA4LPOFDPSRAB9A | |
| SCHEMBL28386445 | 0.82 | CHRNB2 (0.40) | CHRNB2CHRNA4LPOFDPSRAB9A | |
| SCHEMBL16991360 | 0.80 | CHRNB2 (0.40) | CHRNB2CHRNA4LPOFDPSRAB9A | |
| SCHEMBL28324902 | 0.77 | CHRNB2 (0.36) | CHRNB2CHRNA4LPOFDPSRAB9A | |
| SCHEMBL2285950 | 0.77 | KMT2A (0.39) | CHRNB2CHRNA4LPOFDPSRAB9A | |
| SCHEMBL29062266 | 0.77 | ALDH1A1 (0.40) | LMNAALDH1A1 | |
| SCHEMBL2804720 | 0.74 | KMT2A (0.52) | SMN1; SMN2KMT2ALMNATSHRALDH1A1 | |
| SCHEMBL26112999 | 0.73 | ELANE (0.39) | CHRNB2CHRNA4MAPT | |
| SCHEMBL20195592 | 0.73 | — | — | |
| SCHEMBL30689360 | 0.72 | PARP10 (0.54) | RAB9ANPC1KMT2AMYCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |