SCHEMBL6673956

SCHEMBL6673956

COc1c(-c2ccc3c(c2)CNC3C)ccn2c(=O)c(C(=O)O)cc(C3CC3)c12

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CAMKK1 Q8N5S9 1/20 0.30
CAMKK2 Q96RR4 1/20 0.30
PRKAB2 O43741 1/20 0.30
PRKAG1 P54619 1/20 0.30
PRKAA2 P54646 1/20 0.30
PRKAA1 Q13131 1/20 0.30
PRKAG3 Q9UGI9 1/20 0.30
PRKAG2 Q9UGJ0 1/20 0.30
PRKAB1 Q9Y478 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6669074 0.88 CD274 (0.33) CAMKK1CAMKK2
SCHEMBL5432203 0.79 PDE4D (0.36)
SCHEMBL12502230 0.78 MAPK14 (0.39) PRKAA1
SCHEMBL12501938 0.78 ALOX5AP (0.45) CAMKK1CAMKK2
SCHEMBL20083145 0.77 CAMKK1 (0.30) CAMKK1CAMKK2
SCHEMBL3555173 0.76
SCHEMBL6669852 0.74 CAMKK2 (0.33) CAMKK1CAMKK2
SCHEMBL1290293 0.73 SMN1; SMN2 (0.43) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL4962760 0.72 CYP1A2 (0.33)
SCHEMBL12502443 0.72 PIK3CA (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227096-B1 4-OXOQUINOLIZINE ANTIMICROBIALS HAVING 2-PYRIDONE SKELETONS AS THE PARTIAL STRUCTURE SATO PHARMA (JP) 2004-09-22 EP disclosed
US-6525066-B2 Bactericides; side effect reduction SATO PHARMACEUTICAL CO., LTD. (JP) 2003-02-25 US disclosed
US-20020173517-A1 4-Oxoquinolizine antimicrobial having 2-pyridone skeleton as partial structure SATO PHARMACEUTICAL CO., LTD. (JP) 2002-11-21 US disclosed
EP-1227096-A1 4-OXOQUINOLIZINE ANTIMICROBIALS HAVING 2-PYRIDONE SKELETONS AS THE PARTIAL STRUCTURE Sato Pharmaceutical Co. Ltd. (JP) 2002-07-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020173517-A1 4-Oxoquinolizine antimicrobial having 2-pyridone skeleton as partial structure IL4I1, TLR5, IFNG CAMKK1 3356/4885CAMKK2 3507/4885PRKAB2 3483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.