Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KLRK1 | P26718 | 5/20 | 0.39 |
| ▸ | MICA | Q29983 | 5/20 | 0.39 |
| ▸ | RAET1L | Q5VY80 | 5/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676838 | 0.82 | BACE1 (0.45) | BACE1AKR1C3AKR1C2KLRK1MICA | |
| SCHEMBL7040059 | 0.80 | BDKRB1 (0.43) | BACE1AKR1C3AKR1C2FFAR1FFAR4 | |
| SCHEMBL30755131 | 0.80 | BDKRB1 (0.43) | BACE1AKR1C3AKR1C2FFAR1FFAR4 | |
| SCHEMBL8468956 | 0.73 | MTNR1A (0.42) | BACE1PTPN1 | |
| SCHEMBL27371082 | 0.73 | FFAR1 (0.42) | BACE1AKR1C3AKR1C2FFAR1FFAR4 | |
| SCHEMBL5199432 | 0.72 | KIF11 (0.50) | BACE1FFAR1FFAR4PTPN1GSK3B | |
| SCHEMBL12074184 | 0.71 | ENPP1 (0.45) | BACE1FFAR1FFAR4PTPN1GSK3B | |
| SCHEMBL17720756 | 0.71 | FFAR1 (0.47) | BACE1FFAR1FFAR4 | |
| SCHEMBL17697668 | 0.70 | L3MBTL1 (0.43) | BACE1 | |
| SCHEMBL9754847 | 0.70 | KMT2A (0.44) | BACE1FFAR1FFAR4PTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003004020-A1 | HETEROARYL CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-01-16 | — | — | WO | disclosed |