SCHEMBL6674277

SCHEMBL6674277

CN(C)[C@@](C)(Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 2/20 0.59
ESR1 P03372 6/20 0.52
ESR2 Q92731 5/20 0.47
CA2 P00918 2/20 0.42
CAMK2A Q9UQM7 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
TSHR P16473 1/20 0.42
OPRK1 P41145 2/20 0.41
OPRM1 P35372 1/20 0.41
OPRD1 P41143 1/20 0.41
ESRRG P62508 1/20 0.40
MTOR P42345 2/20 0.40
ALDH1A1 P00352 2/20 0.39
CYP3A4 P08684 2/20 0.39
KDM4E B2RXH2 1/20 0.39
USP2 O75604 1/20 0.39
EGFR P00533 1/20 0.39
CYP1A2 P05177 1/20 0.39
FYN P06241 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6725266 1.00 BLM (0.59) BLMESR1ESR2CA2CAMK2A
SCHEMBL28140995 0.85 HIF1A (0.50) MEN1KMT2ATSHROPRK1OPRM1
SCHEMBL31212623 0.85 HIF1A (0.50) MEN1KMT2ATSHROPRK1OPRM1
SCHEMBL498294 0.85 HIF1A (0.50) MEN1KMT2ATSHROPRK1OPRM1
SCHEMBL8933057 0.82 BLM (0.51) BLMESR1ESR2CA2CAMK2A
SCHEMBL6720093 0.81 HSD17B10 (0.62) BLMCA2MEN1KMT2ATSHR
SCHEMBL6720098 0.81 HSD17B10 (0.62) BLMCA2MEN1KMT2ATSHR
SCHEMBL27973999 0.80 BLM (0.53) BLMESR1ESR2CA2CAMK2A
SCHEMBL11596247 0.77 BLM (0.67) BLMESR1ESR2CA2CAMK2A
SCHEMBL5004593 0.77 BLM (0.67) BLMESR1ESR2CA2CAMK2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040101523-A1 Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension G.D. SEARLE & CO. 2004-05-27 US claimed
US-20030220521-A1 Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension G.D. SEARLE & CO. 2003-11-27 US claimed
WO-1996016982-A2 ULTRASELECTIVE OPIOIDMIMETIC PEPTIDES AND PHARMACOLOGICAL AND THERAPEUTIC USES THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-06-06 WO claimed
WO-1992001667-A1 RENAL-SELECTIVE PRODRUGS FOR CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN THE TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1992-02-06 WO claimed
US-20250319152-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING STEALTH BIOTHERAPEUTICS INC. (US) 2025-10-16 US disclosed
EP-4347616-A2 INTRAVITREAL MITOCHONDRIAL-TARGETED PEPTIDE PRODRUGS AND METHODS OF USE Eyedea Bio, Llc (US) 2024-04-10 EP disclosed
WO-2022256377-A2 INTRAVITREAL MITOCHONDRIAL-TARGETED PEPTIDE PRODRUGS AND METHODS OF USE EYEDEA BIO, LLC (US) 2022-12-08 WO disclosed
US-20220296671-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING STEALTH BIOTHERAPEUTICS INC. (US) 2022-09-22 US disclosed
EP-2996707-B1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING STEALTH BIOTHERAPEUTICS CORP (MC) 2019-09-11 EP disclosed
US-20180127465-A1 MULTIFUNCTIONAL OPIOID RECEPTOR LIGANDS AND METHODS OF TREATING PAIN NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-05-10 US disclosed
WO-2016187537-A1 MULTIFUNCTIONAL OPIOID RECEPTOR LIGANDS AND METHODS OF TREATING PAIN THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2016-11-24 WO disclosed
US-20160256514-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING STEALTH BIOTHERAPEUTICS INC. 2016-09-08 US disclosed
WO-2004026293-A2 HEMIASTERLIN DERIVATIVES FOR TREATING RESISTANT TUMORS WYETH HOLDINGS CORPORATION (US) 2004-04-01 WO disclosed
US-20030220521-A1 Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension G.D. SEARLE & CO. 2003-11-27 US disclosed
WO-1996016982-A2 ULTRASELECTIVE OPIOIDMIMETIC PEPTIDES AND PHARMACOLOGICAL AND THERAPEUTIC USES THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-06-06 WO disclosed
EP-0484437-A4 RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION SEARLE & CO (US) 1994-06-01 EP disclosed
EP-0484437-A1 RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION G.D. Searle & Co. (US) 1992-05-13 EP disclosed
WO-1992001667-A1 RENAL-SELECTIVE PRODRUGS FOR CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN THE TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1992-02-06 WO disclosed
WO-1991008759-A1 ALKYL SUBSTITUTED CYCLIC PENICILLANIC ACID PENTAPAPTIDES G.D. SEARLE & CO. (US) 1991-06-27 WO disclosed
WO-1991001724-A1 RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1991-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160256514-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING ARG2, TNNT2, MYLK2 BLM 1592/4885ESR1 4822/4885ESR2 1641/4885
US-20030220521-A1 Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension GLS, APEH, GGH BLM 4877/4885ESR1 4214/4885ESR2 4555/4885
US-20250319152-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING ARG2, TNNT2, MYLK2 BLM 1592/4885ESR1 4822/4885ESR2 1641/4885
US-20220296671-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING ARG2, TNNT2, MYLK2 BLM 1592/4885ESR1 4822/4885ESR2 1641/4885
US-20040101523-A1 Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension GLS, DBH, APEH BLM 4881/4885ESR1 4384/4885ESR2 4614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.