Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.37 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22625308 | 0.78 | MAPT (0.61) | POLBIKBKBDYRK2HSD11B1ALPI | |
| SCHEMBL6673005 | 0.75 | NPC1 (0.55) | POLBALPIMEN1KMT2AALDH1A1 | |
| SCHEMBL6772946 | 0.71 | POLB (0.48) | POLBIKBKBDYRK2HSD11B1ALPI | |
| SCHEMBL29928839 | 0.69 | IKBKB (1.00) | POLBIKBKBDYRK2HSD11B1ALPI | |
| SCHEMBL13719651 | 0.69 | IKBKB (1.00) | POLBIKBKBDYRK2HSD11B1ALPI | |
| SCHEMBL13719652 | 0.69 | IKBKB (1.00) | POLBIKBKBDYRK2HSD11B1ALPI | |
| SCHEMBL1250148 | 0.69 | TTR (0.67) | POLBMEN1KMT2AALDH1A1BLM | |
| SCHEMBL1250147 | 0.69 | TTR (0.67) | POLBMEN1KMT2AALDH1A1BLM | |
| SCHEMBL28401896 | 0.68 | HSD11B1 (0.56) | POLBIKBKBDYRK2HSD11B1ALPI | |
| SCHEMBL2795547 | 0.67 | POLB (0.62) | POLBIKBKBDYRK2HSD11B1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200400-B1 | SUBSTITUTED PYRROLIDIN-2,3,4-TRION DERIVATIVES USEFUL AS NMDA-RECEPTOR ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2004-09-29 | — | — | EP | claimed |